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[China BD 2025] Hengrui and MSD enters a 2 billion USD license for oral Lpa inhibitor HRS-5346

Announced Date: 2025-03-25 (March 25, 2025)

Asset Name: HRS-5346

Licensor: Hengrui Pharma (Jiangsu Hengrui Pharmaceuticals Co., China)

Licensee (Buyer): MSD (Merck & Co., Inc,USA)

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Asset Modality: Small Molecule, oral

Asset Target: Lipoprotein(a) inhibitor , or Lp(a) inhibitor 

Current Stage: Phase II, China

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Scope of Authority:

Hengrui Pharma has granted MSD exclusive rights to develop, manufacture and commercialize HRS-5346 worldwide, excluding Greater China region(China Mainland, Hong Kong, Macau and Taiwan)

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Deal Detail:

Upfront payment of $200 million,

Milestone payments up to  approximately $1.77 billion.

Total 1.97 billion plus

Royalties on net sales,  tiered

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Link:

MSD Enters Exclusive License Agreement for HRS-5346, an Investigational Oral Lipoprotein(a) Inhibitor, for Cardiovascular Disease from Jiangsu Hengrui Pharmaceuticals Co., Ltd.

https://www.msd.com/news/msd-enters-exclusive-license-agreement-for-hrs-5346-an-investigational-oral-lipoproteina-inhibitor-for-cardiovascular-disease-from-jiangsu-hengrui-pharmaceuticals-co-ltd/

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