{"id":82,"date":"2023-12-12T10:00:00","date_gmt":"2023-12-12T10:00:00","guid":{"rendered":"https:\/\/cninmed.com\/en\/?p=82"},"modified":"2025-08-29T00:37:40","modified_gmt":"2025-08-29T00:37:40","slug":"china-bd-deal-2023-systimmune-and-bms-enters-a-8-4-billion-usd-license-on-bispecific-egfrxher3-adc-bl-b01d1","status":"publish","type":"post","link":"https:\/\/cninmed.com\/en\/2023\/82.html","title":{"rendered":"[China BD Deal 2023] SystImmune and BMS enters a 8.4 billion USD license on bispecific EGFRxHER3 ADC\u00a0BL-B01D1"},"content":{"rendered":"\n<p>Announced Date: 2023-12-11 (December 11, 2023)<\/p>\n\n\n\n<p>Asset Name: BL-B01D1 <\/p>\n\n\n\n<p>Licensor: SystImmune Inc., (a member of Sichuan Biokin Pharmaceutical Co., Ltd group., China)<\/p>\n\n\n\n<p>Licensee (Buyer): Bristol Myers Squibb\uff08BMS\uff09<\/p>\n\n\n\n<p>Asset Modality: BsADC\u00a0(bispecific antibody-drug conjugate), topoisomerase inhibitor-based<\/p>\n\n\n\n<p>Asset Target: \u00a0EGFRxHER3 (epidermal growth factor receptor,  human epidermal growth factor receptor 3)<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>\u00a0Potential Indication: \u00a0<strong><em>\u00a0<\/em><\/strong>lung and breast cancer, may expand into additional tumor types<\/p>\n\n\n\n<p>Current Stage: global multi-center Phase 1 study\u00a0<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Scope of Authority:<\/p>\n\n\n\n<p><strong><em>\u00a0<\/em><\/strong>SystImmune and Bristol Myers Squibb to co-develop and co-commercialize BL-B01D1 in the United States; <\/p>\n\n\n\n<p>SystImmune to retain exclusive rights in Mainland China and Bristol Myers Squibb to gain an exclusive license in the rest of the world.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Deal Detail:<\/p>\n\n\n\n<p>Upfront payment of\u00a0 $800 million,<\/p>\n\n\n\n<p>Near-term payments up to $500 million,<\/p>\n\n\n\n<p>Development, regulatory and sales performance milestones payments  up to $\u00a0$7.1 billion,<\/p>\n\n\n\n<p>Total up to $8.4 billion.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Bristol Myers Squibb will receive a royalty on net sales in Mainland China,<\/p>\n\n\n\n<p>SystImmune will receive a tiered royalty on net sales Outside the United States and Mainland China.<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p>Link:\u00a0<\/p>\n\n\n\n<p><a href=\"http:\/\/www.baili-pharm.com\/newsshow.aspx?mid=18&amp;id=1189\">http:\/\/www.baili-pharm.com\/newsshow.aspx?mid=18&amp;id=1189<\/a><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announced Date: 2023-12-11 (December 11, 2023) Asset Name: BL-B01D1 Licensor: SystImmune Inc., (a member of Sichuan &hellip; <a title=\"[China BD Deal 2023] SystImmune and BMS enters a 8.4 billion USD license on bispecific EGFRxHER3 ADC\u00a0BL-B01D1\" class=\"hm-read-more\" href=\"https:\/\/cninmed.com\/en\/2023\/82.html\"><span class=\"screen-reader-text\">[China BD Deal 2023] SystImmune and BMS enters a 8.4 billion USD license on bispecific EGFRxHER3 ADC\u00a0BL-B01D1<\/span>Read more<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-82","post","type-post","status-publish","format-standard","hentry","category-china-license-out"],"_links":{"self":[{"href":"https:\/\/cninmed.com\/en\/wp-json\/wp\/v2\/posts\/82","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/cninmed.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/cninmed.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/cninmed.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/cninmed.com\/en\/wp-json\/wp\/v2\/comments?post=82"}],"version-history":[{"count":3,"href":"https:\/\/cninmed.com\/en\/wp-json\/wp\/v2\/posts\/82\/revisions"}],"predecessor-version":[{"id":85,"href":"https:\/\/cninmed.com\/en\/wp-json\/wp\/v2\/posts\/82\/revisions\/85"}],"wp:attachment":[{"href":"https:\/\/cninmed.com\/en\/wp-json\/wp\/v2\/media?parent=82"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/cninmed.com\/en\/wp-json\/wp\/v2\/categories?post=82"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/cninmed.com\/en\/wp-json\/wp\/v2\/tags?post=82"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}